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目的评价GP方案与塞来昔布合用治疗晚期肺癌的疗效和毒副反应。方法吉西他滨1 000 mg/m2静脉输注,第1、8天;顺铂25 mg/m2静脉滴注第2、3、4天;塞来昔布400 mg每周2次口服,化疗期间连续服用。每21天为1个周期。3个周期后评定疗效。结果完全缓解2例(5.9%),部分缓解12例(35.3%),无变化15例(44.1%),进展5例(14.7%)。总有效率为41.2%。毒性反应主要表现为骨髓功能抑制(中性粒细胞减少、血小板减少)、恶心、呕吐、肝功能损害、脱发。所有毒性反应在停药后或经对症治疗后均恢复正常。结论GP方案与塞来昔布合用治疗晚期肺癌有一定疗效,治疗耐受性良好,且较为安全。
Objective To evaluate the efficacy and side effects of GP regimen combined with celecoxib in the treatment of advanced lung cancer. Methods Gemcitabine 1 000 mg / m2 intravenous infusion, days 1, 8; cisplatin 25 mg / m2 intravenous 2,3,4 days; celecoxib 400 mg twice a week orally, during the continuous administration of chemotherapy . Every 21 days for a cycle. After 3 cycles assessment of efficacy. Results Complete remission in 2 cases (5.9%), partial remission in 12 cases (35.3%), no change in 15 cases (44.1%), progress in 5 cases (14.7%). The total effective rate was 41.2%. Toxicity mainly manifested as bone marrow suppression (neutropenia, thrombocytopenia), nausea, vomiting, liver damage, hair loss. All toxic reactions after stopping or after symptomatic treatment returned to normal. Conclusion GP regimen and celecoxib combined with the treatment of advanced lung cancer have a certain effect, the treatment is well tolerated, and more safer.