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目的探讨轮状病毒肠炎儿童血清锌水平变化及其与体液免疫的相关性。方法对96例轮状病毒肠炎患儿(疾病组)及138例同龄健康儿童(对照组)的血清免疫球蛋白及锌水平进行比较,并分析血清锌及免疫球蛋白水平的变化在疾病组中的相关性。结果轮状病毒肠炎患儿血清锌水平及IgA、IgG水平明显低于对照组(P<0.05),同时疾病组中血清锌与IgA、IgG水平之间存在相关性(r=0.78、0.69,均P<0.05)。结论轮状病毒肠炎儿童免疫功能的降低与血清锌水平的下降存在一定的相关性。
Objective To investigate the serum zinc level in children with rotavirus enteritis and its correlation with humoral immunity. Methods Serum immunoglobulin and zinc levels in 96 children with rotavirus enteritis (disease group) and 138 healthy children of the same age (control group) were compared. The changes of serum zinc and immunoglobulin levels in the disease group Relevance. Results Serum zinc levels and serum levels of IgA and IgG in children with rotavirus enteritis were significantly lower than those in the control group (P <0.05). There was a correlation between serum zinc and IgA and IgG in the disease group (r = 0.78 and 0.69, both P <0.05). Conclusion The decrease of immune function in children with rotavirus enteritis has some correlation with the decrease of serum zinc level.