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目的:建立并分析一个可用于研究2型糖尿病遗传和环境危险因素的高发家系人群。方法:确定有家族史2型糖尿病家系183个,分别对其三代家族史和血统成员进行调查研究,全部非患者进行葡萄糖耐量试验(OGTT),用免疫学方法排除1型糖尿病家系。结果:家系人群中2型糖尿病患病率是56.5%,高于普通人群患病率。将家系人群按年龄分组,40岁以后患病率显著增高,不同年龄组的患病率有显著性差异(P<0.01)。本研究家系人群中母亲传递的糖尿病显著多于父亲(45.9%∶26.7%,P<0.01)。但母亲是糖尿病的子女和父亲是糖尿病子女的患病率无显著差异(43.5%∶41.6%,P>0.05)。结论:有家族史的2型糖尿病患者有明显的家族聚集性,家系人群是研究2型糖尿病发病遗传因素和环境因素的合适人群。
OBJECTIVE: To establish and analyze a high incidence of familial population that can be used to study genetic and environmental risk factors for type 2 diabetes. Methods: A total of 183 pedigrees with family history of type 2 diabetes mellitus were determined. Three generations of family history and descent members were investigated. All non-patients underwent glucose tolerance test (OGTT) and type 1 diabetes families were excluded by immunological method. Results: The prevalence of type 2 diabetes in pedigree population was 56.5%, higher than the prevalence in general population. The family members by age groups, the prevalence after 40 years of age was significantly higher, the prevalence of different age groups were significantly different (P <0.01). Mothers in the study pedigrees had significantly more diabetes than fathers (45.9%, 26.7%, P <0.01). However, there was no significant difference in the prevalence of diabetic children whose mother was diabetic and their father was diabetic (43.5%: 41.6%, P> 0.05). Conclusion: Type 2 diabetes patients with family history have significant familial aggregation. Family members are the appropriate population to study the genetic and environmental factors of type 2 diabetes.