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目的 :为探讨超高速 CT检测的冠状动脉钙化与冠状动脉粥样硬化面积之间的关系。方法 :从 8例 (年龄在4 2～ 84岁 )压力灌注固定后的心脏标本中分离出 2 0支冠状动脉 ,拉直后 ,超高速 CT扫描 ;每支冠状动脉分成相应的 3mm血管段 ,组织切片 ,地衣红染色 ,L eica图像分析仪上计算粥样硬化面积。结果 :在血管、心脏水平 ,总的粥样硬化面积与钙化面积、钙化积分高度相关 ,在血管段水平 ,每个标本内粥样硬化面积与钙化面积、钙化积分呈等级相关 ;有一些粥样斑块的血管段 ,超高速 CT未检测出钙化。结论 :超高速 CT检则的钙化参数与粥样硬化面积在血管、心脏水平高度相关 ;能检出钙化的血管段 ,其粥样斑块面积可能有一定的阈值。
Objective: To investigate the relationship between coronary artery calcification and coronary atherosclerosis area by ultra-high-speed CT. METHODS: Twenty coronary arteries were isolated from 8 cardiac samples (aged 4 to 84 years old) under pressure-perfusion fixation. After straightening, they were scanned by ultra-high-speed CT. Each coronary artery was divided into 3 mm segments, Tissue sections, lichen red staining, and L eica image analyzer were used to calculate the area of atherosclerosis. Results: At the level of blood vessels and heart, the total area of atherosclerosis was highly correlated with the area of calcification and the score of calcification. At the level of blood vessel, the area of atherosclerosis in each specimen was related to the area of calcification and the score of calcification. Plaque vascular segments, ultra-high-speed CT did not detect calcification. CONCLUSIONS: The calcification parameters of ultra-high-speed computed tomography are highly correlated with the area of atherosclerosis at the level of blood vessels and heart. Calcified vascular segments can be detected, and the atherosclerotic plaque area may have a certain threshold.