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三七三醇甙(PTS)为三七的组分之一,能明显对抗乌头碱、BaCl_2和肾上腺素诱发的实验性心律失常。PTS减慢大鼠心率,延长P-R和Q-Tc间期;减慢离体豚鼠右房自发频率;使异丙肾上腺素加速右房自发频率的量效-曲线右移并抑制最大效应。PTS与胺碘达隆作用相似,使离体豚鼠乳头状肌细胞电位APD和ERP显著延长,2相复极化斜率降低。PTS对上述动作电位的影响呈剂量依赖性关系。
PTS, one of the components of Panax notoginseng, can obviously antagonize aconitine, BaCl 2 and epinephrine induced experimental arrhythmia. PTS slows the heart rate, prolongs the interval between P-R and Q-Tc, slows the spontaneous spontaneous frequency of isolated right atrium in isolated guinea pigs, and shifts the dose-response of isoprenaline to accelerate the right atrial spontaneous frequency to the right and inhibits the maximal effect. PTS and amiodarone similar effect, so that isolated guinea pig papillary muscle cell potential APD and ERP significantly prolonged, 2-phase repolarization decreased the slope. PTS on the action potential in a dose-dependent manner.