论文部分内容阅读
目的对比性研究联合应用阿托品和盐酸戊乙奎醚(联合组)与单独应用阿托品(对照组)在治疗急性有机磷农药中毒的临床疗效。方法回顾性调查分析2007年1月-2010年12月大庆油田总医院收治的87例急性有机磷农药中毒患者,根据治疗方式不同分为联合组和对照组。联合组早期应用阿托品达阿托品化后停用阿托品,开始应用盐酸戊乙奎醚治疗直至病情缓解,对照组只应用阿托品治疗。观察治愈率、病死率、中毒症状持续时间、胆碱酯酶恢复时间、药物不良反应发生率、住院天数等指标。结果联合组43例患者死亡1例,对照组44例患者死亡4例。联合组与对照组相比,联合组具有治愈率提高(P<0.05)、病死率降低(P<0.05)、胆碱酯酶恢复时间缩短(P<0.01)、中毒症状持续时间缩短(P<0.01)、药物不良反应发生率减少(P<0.01)、住院天数减少(P<0.01)等优点。结论阿托品联合盐酸戊乙奎醚治疗急性有机磷农药中毒临床疗效优于单独应用阿托品治疗,值得在临床推广。
Objective To compare the clinical efficacy of combination of atropine and penehyclidine hydrochloride (combination group) with atropine (control group) alone in the treatment of acute organophosphorus pesticide poisoning. Methods Retrospective analysis of 87 patients with acute organophosphorus pesticide poisoning admitted to Daqing Oilfield General Hospital from January 2007 to December 2010 was divided into combined group and control group according to different treatment methods. In the combined group, atropine and atropine were used to deactivate atropine after the early application of atropine, and penehyclidine hydrochloride was started until the disease was relieved. The control group was treated with atropine only. Observe the cure rate, case fatality rate, the duration of poisoning symptoms, cholinesterase recovery time, the incidence of adverse drug reactions, hospitalization days and other indicators. Results The combined group of 43 patients died in 1 case, the control group of 44 patients died in 4 cases. Compared with the control group, the combined group had higher cure rate (P <0.05), lower mortality (P <0.05), shorter recovery time of cholinesterase (P <0.01) and shorter duration of poisoning symptoms (P < 0.01), the incidence of adverse drug reactions decreased (P <0.01), hospital days decreased (P <0.01) and so on. Conclusions The combination of atropine and penehyclidine hydrochloride for the treatment of acute organophosphorus pesticide poisoning is superior to the treatment of atropine alone, which is worthy of clinical application.