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目的:研究红细胞膜反式脂肪酸(TFA)及血浆氨基酸含量与代谢综合症(MS)的相关性。方法:选取2015年7~12月,237例40~65岁人群作为研究对象,根据临床诊断结果分为MS组(33例)与非MS组(NMS组,204例),统计和比较两组的人口学资料、基本健康指标(身高、体重、血压、腰围)以及实验室指标(血脂、血糖、血浆氨基酸含量及TFA构成)。结果:MS患病率为13.92%(33/237);MS组的支链氨基酸(异亮氨酸、缬氨酸、亮氨酸)以及生酮氨基酸(赖氨酸、苯丙氨酸)含量均明显高于NMS组,而生糖氨基酸(丝氨酸、甘氨酸、丙氨酸、苏氨酸)含量明显低于NMS组;MS组的反式18:1脂肪酸(t18:1)及反式16:1脂肪酸(t16:1)构成均明显高于NMS组,反式/顺式16:1脂肪酸(t16:1/c16:1)比例明显降低,而反式/顺式18:1脂肪酸(t18:1/c18:1)比例明显升高;相关性分析显示,支链氨基酸及生酮氨基酸与MS的发生呈显著正相关性,成糖氨基酸与MS的发生呈显著负相关性,t18:1及t16:1均与MS呈显著正相关性。结论:MS患者存在明显的TFA构成及氨基酸代谢异常,TFA构成降低、血浆支链与生酮氨基酸含量降低、血浆生糖氨基酸含量升高与MS的发生密切相关。
Objective: To study the correlation between trans-fatty acid (TFA) and plasma amino acid level in plasma membrane and metabolic syndrome (MS). Methods: From July 2015 to July 2015, 237 cases aged 40-65 years old were selected as the research objects. According to the clinical diagnosis results, they were divided into two groups: MS group (33 cases) and non-MS group (204 cases) Demographic data, basic health indicators (height, weight, blood pressure, waist circumference) and laboratory parameters (lipids, blood glucose, plasma amino acids and TFA). Results: The prevalence of MS was 13.92% (33/237). The contents of branched-chain amino acids (isoleucine, valine, leucine) and ketogenic amino acids (lysine, phenylalanine) Were significantly higher than those in the NMS group (P <0.05). However, the contents of glycogenic amino acids (serine, glycine, alanine and threonine) were significantly lower than those in the NMS group. 1 fatty acids (t16: 1) were significantly higher than that of the NMS group. The ratio of trans / cis 16: 1 fatty acids (t16: 1 / c16: 1 / c18: 1). The correlation analysis showed that there was a significant positive correlation between branched-chain amino acids and ketogenic amino acids and the occurrence of MS. There was a significant negative correlation between the formation of MS and glycosaminoglycans (t18: 1 and There was a significant positive correlation between t16: 1 and MS. CONCLUSIONS: MS patients have obvious TFA constitution and abnormal amino acid metabolism, TFA composition is reduced, plasma branching and ketogenic amino acid content is decreased, and plasma glycoengine content is closely related to the occurrence of MS.