论文部分内容阅读
目的分析高血压并糖尿病患者血清肿瘤坏死因子-α(TNF-α)水平与左心室舒张功能参数二尖瓣舒张早期峰值血流速度与二尖瓣环舒张早期峰值运动速度均值之比(E/Em值)相关性。方法入选正常对照组(A组)58例,单纯高血压患者(B组)66例,单纯2型糖尿病患者(C组)60例,高血压并2型糖尿病患者(D组)62例,用组织多普勒超声心动图测定四组左心室舒张功能参数E/Em值,并用酶联免疫吸附法测定各组血清TNF-α浓度。分别比较四组的E/Em值,血清TNF-α浓度,及两者的相关系数。结果 D组E/Em值,血清TNF-α浓度,及两者相关系数均高于A组、B组和C组,差异具有统计学意义。[E/Em值,D组:(11.4±3.9)比A组:(8.6±3.3)P<0.05,B组:(10.4±3.4)P<0.05,C组:(10.0±3.0)P<0.05],[血清TNF-α浓度,D组:(13.6±5.9)ng/L比A组:(7.2±2.0)ng/L P<0.05,B组:(10.9±5.0)ng/L P<0.05,C组:(10.3±4.1)ng/L P<0.05],[两者相关系数,D组:0.734比B组:0.643,C组:0.675〗。结论与单纯高血压和单纯2型糖尿病患者相比高血压并2型糖尿病患者血清TNF-α浓度和左心室舒张功能参数E/Em值明显升高,两者正相关性更强。
Objective To analyze the relationship between the serum level of tumor necrosis factor-α (TNF-α) and left ventricular diastolic function in patients with hypertension and type 2 diabetes mellitus (E (subscript m) / Em value) correlation. Methods Sixty-eight patients with normal control (group A), 66 patients with simple hypertension (group B), 60 patients with simple type 2 diabetes mellitus (group C), 62 patients with hypertension and type 2 diabetes mellitus (group D) Tissue Doppler echocardiography was used to measure left ventricular diastolic function parameters E / Em, and serum TNF-α levels were determined by enzyme-linked immunosorbent assay. The E / Em value, serum TNF-α concentration and the correlation coefficient between the two groups were compared respectively. Results The E / Em value, serum TNF-α concentration and the correlation coefficient between the two groups were higher than those in group A, group B and group C, the difference was statistically significant. [E / Em value in group D: (11.4 ± 3.9) vs (8.6 ± 3.3) P <0.05 in group D, (10.4 ± 3.4) P < (13 ± 5.9) ng / L in group D was (7.2 ± 2.0) ng / LP less than 0.05 in group D and (10.9 ± 5.0) ng / L Group: (10.3 ± 4.1) ng / LP <0.05], [correlation coefficient between the two groups, group D: 0.734 vs group B: 0.643, group C: 0.675. Conclusions Serum TNF-α level and left ventricular diastolic function parameter E / Em are significantly higher in hypertensive patients with type 2 diabetes mellitus than those with simple hypertension and simple type 2 diabetes mellitus.