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损伤性骨病变是多发性骨髓瘤(MM)的显著特征,已有较多的证据表明:骨损伤的机理与破骨细胞激活因子(OAF)有关,白介素1(IL-1)是其中主要因子.我们已报道,MM伴骨损伤患者骨髓培养上清具有明显的骨吸收性(BRA),上清中IL-1活性水平增高.为进一步探讨骨损伤的治疗方法,本实验选用临床治疗骨病变选用的地塞米松、降钙素、骨磷和三样中药复方(三七活血汤、跌打营养汤、三骨汤)来研究它们对MM~3中骨吸收因子(IL-1)和骨髓瘤细胞KM_3培养上清的骨吸收作用影响.
Damaged bone lesions are the hallmark feature of multiple myeloma (MM). There is more evidence that the mechanism of bone injury is related to osteoclast activating factor (OAF), and interleukin-1 (IL-1) is the main factor. We have reported that the bone marrow culture supernatant of MM with bone injury has obvious bone resorption (BRA), and the level of IL-1 activity in the supernatant is increased. To further explore the treatment of bone damage, this study used clinical treatment of bone disease. Selected dexamethasone, calcitonin, bone phospho, and three kinds of Chinese herbal compound (Sanqi Huoxue Decoction, Yan Dao Decoction, and San Gu Decoction) to study their effects on bone resorption factor (IL-1) and bone marrow in MM~3 The effect of bone resorption on the culture supernatant of tumor cells KM_3.