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目的:观察顺尔宁联合吸入型糖皮质激素治疗小儿哮喘的疗效及对外周血嗜酸性粒细胞(Eos)的影响。方法:将2010年6月～2011年6月92例小儿哮喘患儿随机分为两组,观察组46例采用顺尔宁联合布地奈德治疗,对照组46例仅采用布地奈德治疗,观察两组的疗效、肺功能及外周血嗜酸性粒细胞的变化。结果:观察组的显效率为93.5%,明显高于对照组的76.1%(P<0.05),而两组总有效率比较,差异无统计学意义(P>0.05)。两组治疗后FEV1、PEF水平明显升高(P<0.05),Eos明显降低(P<0.05)。观察组治疗后FEV1、PEF水平明显高于同期对照组(P<0.05),而Eos明显低于同期对照组(P<0.05)。结论:顺尔宁联合吸入型激素治疗小儿哮喘进行治疗,能够明显提高临床疗效,改善肺功能,降低外周血Eos水平,值得临床推广应用。
Objective: To observe the therapeutic effect of combination of sotalin and inhaled glucocorticoids on pediatric asthma and its effect on peripheral blood eosinophil (Eos). Methods: From June 2010 to June 2011, 92 children with asthma were randomly divided into two groups. 46 cases in the observation group were treated with Salbutamol combined with budesonide, and 46 cases in the control group were treated with budesonide alone. Efficacy of the two groups, lung function and peripheral blood eosinophil changes. Results: The markedly effective rate in the observation group was 93.5%, which was significantly higher than 76.1% in the control group (P <0.05). There was no significant difference in the total effective rate between the two groups (P> 0.05). The FEV1 and PEF levels in both groups were significantly increased (P <0.05) and Eos significantly decreased after treatment (P <0.05). The FEV1 and PEF levels in the observation group were significantly higher than those in the control group (P <0.05), while Eos was significantly lower than that in the control group (P <0.05). Conclusion: Treatment of pediatric asthma with combination of inhaled corticosteroids and paracetamol can significantly improve clinical curative effect, improve lung function and reduce peripheral blood Eos level, which is worthy of clinical application.