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目的观察卡维地洛治疗慢性心力衰竭的临床疗效。方法慢性心衰患者69例,随机分为常规治疗组34例和卡维地洛治疗组35例。常规治疗组用强心、利尿药和扩血管药物治疗,卡维地洛治疗组在常规治疗药物的基础上加用卡维地洛,疗程8周。观察其临床效果并测定治疗前后左心室射血分数(LVFF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)的变化。结果治疗8周后,卡维地洛治疗组总有效率高于常规治疗组(P<0.05),卡维地洛治疗组LVFF、LVEDD、LVESD与常规治疗组比较,差异均有统计学意义(P<0.01,P<0.05)。结论卡维地洛治疗慢性心力衰竭疗效可靠,可改善心肌功能。
Objective To observe the clinical efficacy of carvedilol in the treatment of chronic heart failure. Methods 69 patients with chronic heart failure were randomly divided into routine treatment group 34 cases and carvedilol treatment group 35 cases. Conventional treatment group with cardiac, diuretic and vasodilator drug treatment, carvedilol treatment group on the basis of conventional treatment with carvedilol treatment for 8 weeks. The clinical effects were observed and the changes of left ventricular ejection fraction (LVFF), left ventricular end-diastolic dimension (LVEDD) and left ventricular end-systolic diameter (LVESD) before and after treatment were measured. Results After 8 weeks of treatment, the total effective rate of carvedilol treatment group was higher than that of conventional treatment group (P <0.05). The differences of LVFF, LVEDD and LVESD between carvedilol group and routine treatment group were statistically significant P <0.01, P <0.05). Conclusion Carvedilol is effective in treating chronic heart failure and can improve myocardial function.