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研究了儿童时期发病的SLE患儿的临床表现,并检测了其自身抗体和HLAⅡ类等位基因的发生频率。 病例:80例儿童SLE,发病年龄均<18岁,其中38例为白人儿童(男7例,女31例),29例黑人儿童(男4例,女25例),13例亚洲儿童(男1例,女12例)。根据发病年龄将患儿分为<11岁组(27例中男2例,女25例)和11～18岁组(53例中男10例,女43例)。另外对213例成人SLE,发病年龄≥18岁者进行了对比研究。全部患者均具备美国风湿病学会(ARA)制定的SLE诊断标准中的4条或4条以上。观察下列SLE临床表现
The clinical manifestations of children with SLE during childhood were studied and the frequency of their autoantibodies and HLA class II alleles was examined. Case: SLE in 80 children <18 years of age, of whom 38 were white children (7 males and 31 females), 29 were black children (4 males and 25 females), and 13 Asian children (male 1 case, 12 females). According to the age of onset, the children were divided into <11 group (27 males and 25 females) and 11-18 age groups (53 males and 10 females, 43 females). In addition 213 cases of adult SLE, age of onset ≥ 18 years were compared. All patients had 4 or more SLE diagnostic criteria developed by the American College of Rheumatology (ARA). Observe the following SLE clinical manifestations