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33名消化不良病人作纤维胃镜检查,每例均作过内窥镜诊断并作多个活检,以供组织学及电子显微镜检查用。内窥镜组织学及电子显微镜的发现相互比较。33例内窥镜检查中,29例有各型胃炎,并经组织学证明为某种类型的胃炎。但内窥镜诊断的胃炎。仅有3/9病例组织学证实为萎缩性胃炎,10/14病例证实为慢性浅表性胃炎。6名急性胃炎中,无一例得到组织学的证实,说明内窥镜诊断胃炎的精确分型是不准确的。所以,内窥镜诊断只限于有否胃炎,而精确分型则需组织学证实;即使内窥镜下胃粘膜正常,也应多取几个活检材料,因为内窥镜检查4例正常胃粘膜中,三例组织学证明是胃炎。作者的研究中,组织学诊断与电子显微镜比较,一般地说,组织学改变的严重程度与超微结构,对损害的分级关系是密切的,然而电子显微镜胃活检与光学显微镜相比并未显著增加其精确性,虽然它可显示慢性胃炎特殊的种种细胞性改变,扫描、电子显微镜所看到的粗糙表面轮廓、大的胃小凹以及表面微绒毛数目的坛加等,有助于疾病过程的分级。某些改变可以在透射电子显微镜下反映出来。它还可以显示粘膜基底部细胞间水肿,以及高电子密度的粘膜被复细胞,后者与“肠上皮代生”相当。
Thirty-three patients with indigestion underwent fiberoptic gastroscopy. Each patient had undergone endoscopic diagnosis and multiple biopsies for histology and electron microscopy. Endoscopic histology and electron microscopy findings were compared with each other. In 33 cases of endoscopy, 29 cases had various types of gastritis, and histology proved to be a certain type of gastritis. However, endoscopic diagnosis of gastritis. Only 3/9 of the cases were histologically proven to be atrophic gastritis and 10/14 of the cases was chronic superficial gastritis. Among 6 acute gastritis cases, no case was confirmed by histology, indicating that the precise classification of endoscopic gastritis is inaccurate. Therefore, endoscopic diagnosis is limited to the presence or absence of gastritis, and accurate classification requires histological confirmation; even if the endoscopic gastric mucosa is normal, it should also take a few more biopsy material, because the endoscopy examination of 4 cases of normal gastric mucosa Of the three cases, histology proved to be gastritis. In the author’s study, histological diagnosis was compared with electron microscopy. Generally speaking, the severity of histological changes and ultrastructure were closely related to the classification of lesions, whereas electron microscopy was not significantly different from light microscopy. Increasing its accuracy, although it can show a variety of specific cellular changes in chronic gastritis, scanning, electron microscope observation of the rough surface contours, large gastric pits, and alveolar plus the number of surface microvilli, contribute to the disease process Rating. Some of the changes can be reflected under a transmission electron microscope. It can also show intercellular edema of the mucosal base and mucosal complex cells with high electron density, the latter being equivalent to “intestinal epithelium”.