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目的:评价液基细胞学(LPT)薄片制片对宫颈癌筛查的准确性。方法:对3600例和2200例受检者分别进行LPT制片和传统宫颈细胞涂片法进行宫颈癌筛查。细胞诊断采用TBS分级系统,阳性诊断包括意义不明的不典型鳞状上皮(ASCUS)以上病变。所有ASCUS以上病变的受检者全部在阴道镜下活检。结果:LPT薄片法和传统涂片法对ASCUS以上病变检出阳性率分别为10.5%和5.2%,两种检测方法的阳性率差异有统计学意义(P<0.01);两种制片方法的阳性结果与病理检查符合率比较:LPT薄片法检出SCC、HSIL、LSIL与阴道镜活检阳性符合率分别为100%、91%、82%,传统宫颈巴氏涂片法检出SCC、HSIL、LSIL与阴道镜活检阳性符合率分别为100%、60%、53%,两种方法比较差异有统计学意义(P<0.05)。结论:LPT液基细胞学检查敏感性明显高于传统宫颈细胞涂片法,能大大提高检出率,尤其是对宫颈癌前筛查的患者。
OBJECTIVE: To evaluate the accuracy of liquid-based cytology (LPT) flake screening for cervical cancer screening. Methods: 3600 and 2200 subjects underwent LPT and conventional cervical smears for cervical cancer screening. Cell diagnosis using the TBS classification system, positive diagnosis includes atypical unspecified squamous epithelium (ASCUS) lesions above. All subjects with ASCUS lesions were biopsied under colposcopy. Results: The positive rates of LPT and conventional smears were 10.5% and 5.2%, respectively. The positive rates of the two methods were statistically significant (P <0.01). The positive rates of the two methods were The coincidence rates of positive results and pathological findings showed that the positive coincidence rates of SCC, HSIL, LSIL and colposcopy biopsy were 100%, 91% and 82%, respectively. The traditional cervical Pap smear method detected SCC, HSIL, The positive coincidence rates of LSIL and colposcopy biopsy were 100%, 60% and 53%, respectively. There was significant difference between the two methods (P <0.05). Conclusion: The sensitivity of LPT liquid-based cytology test is significantly higher than that of traditional cervical smear method, which can greatly improve the detection rate, especially in patients with pre-cervical cancer screening.