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目的 探讨血清热应激蛋白 70 (HSP70 )抗体作为工人长期接触某些环境应激后健康监测指标的可行性。方法 采用Westernblot免疫印迹法检测接触不同有害作业环境因素和相对无有害接触的某钢铁企业 76 4名职工的血清HSP70抗体水平。结果 在排除年龄、工龄以及性别的影响后 ,多种有害接触均可使工人血清HSP70抗体水平升高。暴露于有害环境 ,如高温和粉尘的联合暴露 ,以及粉尘 (石灰 )暴露和噪声暴露工人血清HSP70抗体水平均明显高于对照组 (OR值为 2 .35 6 3～3.15 2 6 ,P <0 .0 1) ,而且噪声组工龄与HSP70抗体的产生具有相关性 ,且差异有显著性 (OR =2 .0 40 6 ,P =0 .0 10 3)。结论 血清HSP70抗体水平有可能作为评价工人经历某些环境应激 (如粉尘、噪声 )的血清学标记物或环境危害监测指标。
Objective To investigate the feasibility of serum heat stress protein 70 (HSP70) antibody as a health monitoring index after long-term exposure to certain environmental stress. Methods Western blot Western blot was used to detect the level of serum HSP70 in 76 4 workers in an iron and steel enterprise exposed to different harmful environmental factors and relatively no harmful contact. Results Excluding the influence of age, length of service and sex, workers’ serum HSP70 antibody level could be increased by a variety of harmful contacts. The level of serum HSP70 antibody in exposed workers exposed to harmful environment, such as high temperature and dust, as well as workers exposed to dust (lime) and noise were significantly higher than those in the control group (OR = 2.363-3.1562, P <0 .0 1). And the length of service in noise group was correlated with the production of HSP70 antibody (OR = 2.0406, P = 0.0103). Conclusions The level of serum HSP70 antibody may be used as a serological marker or indicator of environmental risk in evaluating workers’ exposure to certain environmental stressors such as dust and noise.