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200余名健康青年分两组分别接种酵母重组乙型肝炎疫苗(YDV)和血源性乙型肝炎疫苗(PDV)。免疫程序为0、1和2个月或0、1和6个月,接种剂量均为20μg。0、1和2个月程序组于12个月时再加强接种1剂20μgYDV。用放射免疫法检测血清抗-HBs水平。对138名青年随访了3年。接种YDV者在注射部位出现轻微疼痛,并有短暂的疲劳和头痛,没有不可接受的副反应。按0、1和6个月程序接种3针后1个月,两组的血清阳转率均为100%,仅1人抗-HBs滴度<100mIU/ml。接种后36个月,接种
More than 200 healthy young people were vaccinated with yeast recombinant hepatitis B vaccine (YDV) and blood-borne hepatitis B vaccine (PDV) in two groups. The immunization schedule was 0, 1 and 2 months or 0, 1 and 6 months with a dose of 20 μg. The 0, 1, and 2-month program groups were further boosted with one dose of 20 μg ofYDV at 12 months. Serum anti-HBs levels were measured by radioimmunoassay. 138 young people were followed for 3 years. Those who were vaccinated with YDV developed mild pain at the injection site with brief fatigue and headaches without unacceptable side effects. One month after inoculation of 3 needles with 0, 1, and 6-month programs, seroconversion rates were 100% for both groups, with only 1 human anti-HBs titer <100 mlU / ml. 36 months after inoculation