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目的探讨血液透析治疗对急性敌敌畏中毒合并急性乙醇中毒患者肝损害的临床疗效。方法将63例急性重度敌敌畏中毒合并乙醇中毒患者分为非透析治疗组(23例)与透析治疗组(40例),动态观察2组患者的肝功能、白蛋白含量和血清胆碱酯酶活力变化情况。结果 2组患者在性别、年龄、血中敌敌畏含量、乙醇含量、就诊时间上差异无统计学意义(P>0.05);非透析组患者死亡率高于透析组(P<0.05);血液透析治疗组在入院后12、24、48、72 h肝功能及胆碱酯酶活力恢复明显快于非透析组,2组差异有统计学意义;血液透析组白蛋白水平在入院后12、24、48、72 h低于非透析组,2组差异有统计学意义。结论血液透析治疗可促进急性敌敌畏中毒合并乙醇中毒患者肝功能及血清胆碱酯酶活力的恢复,对于此类混合中毒,是一种有效的治疗手段。
Objective To investigate the clinical effect of hemodialysis on liver damage in acute dichlorvos poisoning patients with acute alcoholism. Methods Sixty-three patients with acute severe dichlorvos poisoning and alcoholism were divided into non-dialysis group (n = 23) and dialysis group (n = 40). The liver function, serum albumin and serum cholinesterase Changes. Results There were no significant differences in sex, age, blood levels of dichlorvos, alcohol content, and the time of visiting the patients in the two groups (P> 0.05). The mortality of the non-dialysis group was higher than that of the dialysis group (P <0.05) In the group 12, 24, 48, 72 h after liver function and recovery of cholinesterase activity was significantly faster than non-dialysis group, the difference between the two groups was statistically significant; hemodialysis group albumin levels after admission 12,24,48 , 72 h lower than non-dialysis group, the difference between the two groups was statistically significant. Conclusion Hemodialysis can promote the recovery of liver function and serum cholinesterase activity in patients with acute dichlorvos poisoning and alcohol poisoning, which is an effective treatment for such poisoning.