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我院于1974～1984年,采用狄高辛维持疗法(0.125～0.375mg,每日一次)治疗充血性心力衰竭1324例,疗效满意,但有81例发生中毒症状,发生率为6.11%。本组发生中毒原因与下列因素有关:(1)老年人缺血性心脏病常见,心肌对狄高辛的耐受性降低,加之老年人肾脏对狄高辛的清除率降低,故易蓄积中毒,本组60岁以上36例占44%;(2)心力衰竭合并上呼吸道感染占46%;(3)肾功能减退,易发生狄高辛在体内蓄积,而致中毒,本组8例占10%;
Our hospital from 1974 to 1984, the use of digoxin maintenance therapy (0.125 ~ 0.375mg, once daily) to treat 1324 cases of congestive heart failure, the effect is satisfactory, but there are 81 cases of poisoning symptoms, the incidence was 6.11%. This group of causes of poisoning and the following factors: (1) common in elderly ischemic heart disease, myocardial resistance to digoxin reduced, combined with the elderly kidneys reduce the clearance of digoxin, it is easy to accumulate poisoning , This group of 36 patients over the age of 44 accounted for 44%; (2) heart failure combined with upper respiratory tract infection accounted for 46%; (3) renal dysfunction, prone to digoxin accumulation in the body, resulting in poisoning, the group of 8 patients 10%;