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目的评估降钙素原(PCT)联合腺苷脱氨酶(ADA)检测对结核性胸腔积液的诊断价值。方法检测30例结核性胸腔积液患者治疗前和抗结核治疗1周后(A组)和30例恶性胸腔积液患者(B组)胸腔积液中PCT和ADA水平。结果 A组胸腔积液中PCT和ADA水平均高于B组[(0.25±0.08)ng/ml vs.(0.12±0.06)ng/ml和(50.35±10.47)IU/L vs.(18.87±5.67)IU/L](P<0.05)。联合检测PCT和ADA对结核性胸腔积液的检出效果优于单独ADA检测(P<0.05)。与治疗前相比,A组治疗后胸腔积液中PCT和ADA水平降低[(0.09±0.03)ng/ml vs.(0.25±0.08)ng/ml和(17.68±3.51)IU/L vs.(50.35±10.47)IU/L](P<0.05)。结论联合检测PCT和ADA可提高结核性胸腔积液的检出率;动态观察结核性胸腔积液中PCT和ADA水平的变化有助于评估抗结核治疗效果。
Objective To evaluate the diagnostic value of procalcitonin (PCT) combined with adenosine deaminase (ADA) in the diagnosis of tuberculous pleural effusion. Methods The levels of PCT and ADA in pleural effusion of 30 patients with tuberculous pleural effusion before treatment and one week after anti-TB treatment (group A) and 30 patients with malignant pleural effusion (group B) were measured. Results The levels of PCT and ADA in pleural effusion in group A were significantly higher than those in group B [(0.25 ± 0.08) ng / ml vs. (0.12 ± 0.06) ng / ml and (50.35 ± 10.47) IU / L vs. (18.87 ± 5.67 ) IU / L] (P <0.05). The combined detection of PCT and ADA showed better detection of tuberculous pleural effusion than ADA alone (P <0.05). The PCT and ADA levels in pleural effusions in group A were significantly lower than those before treatment [(0.09 ± 0.03) ng / ml vs. (0.25 ± 0.08) ng / ml vs (17.68 ± 3.51) IU / L vs. 50.35 ± 10.47) IU / L] (P <0.05). Conclusions The combined detection of PCT and ADA can improve the detection rate of tuberculous pleural effusion. Dynamic changes of PCT and ADA levels in tuberculous pleural effusion can help to evaluate the efficacy of anti-TB treatment.