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溴丁东莨菪碱(N-Butylscopolammonium Bromide, Buscopan)化学名为:溴化8-丁基-6,7-环氧-3α-羟基-1αH,5αH-托品烷铵(-)托品酸酯。其结构式如下: 本品首先由德国于1950年合成,此后对其药理、临床和体内代谢进行了较深入的研究。其药理作用曾与阿托品、东莨菪碱及其衍生物进行比较。本品对平滑肌解痉作用与阿托品相似,而对心脏、扩瞳、中枢神经的副作用则比阿托品小得多。在临床上可用于治疗休克病人的Ⅰ、Ⅱ期血管平滑肌痉挛、胆肾绞痛、痉挛性痛经、宫颈口开放不全难产、胃肠痉挛性疼痛等。
The chemical name of N-Butylscopolammonium Bromide (Buscopan) is: 8-Butyl-6,7-epoxy-3α-hydroxy-1αH, 5αH-tropanin (-) tropicate. Its structure is as follows: This product was first synthesized in Germany in 1950, after its pharmacological, clinical and in vivo metabolism conducted a more in-depth study. Its pharmacological effects have been compared with atropine, scopolamine and their derivatives. This product on the role of smooth muscle spasm and atropine similar to the heart, dilation, central nervous side effects are much smaller than atropine. Clinic can be used to treat patients with stage Ⅰ, Ⅱ vascular smooth muscle spasm, gallbladder colic, spastic dysmenorrhea, cervical insufficiency, gastrointestinal spasmodic pain and so on.