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麻醉犬实验表明枳实及其有效成分辛弗林和N-甲基酪胺与多巴胺、多巴酚丁胺相似,能显著增强多种心肌收缩性和泵血功能的指标:增大左室压变化速率峰值和在共同最高等容收缩压(CPIP)时的心肌收缩成分的缩短速率(V_(CE)),增加心脏指数(GI),缩短左室从开始收缩到开始射血的时间,降低左室舒张末压。由于在CPIP时的V_(CE)不受心室后负荷(动脉压)的影响,故可以排除上述指标的增强是由于药物对血压的影响。由于枳实及其有效成分的强心、增加心输出量和收缩血管提高总外周阻力,导致左室压力和动脉血压上升,这是它们抗休克的药理学基础。N-甲基酪胺升高外周阻力的作用比枳实和辛弗林稍弱,但加快心率的作用则较强。这两种成分在作用上是各有特点的。在增加心搏指数等效剂量下,枳实、辛弗林、N-甲基酪胺与大剂量多巴胺增加左室作功指数和射血的张力-时间指数的比值远超过增加心搏指数的百分率,这可能是升压增加左室后负荷造成的。多巴酚丁胺和小剂量多巴胺不同于枳实及其有效成分在于能降低外周血管阻力,降低动脉血压,而不明显增加左室作功指数和射血的张力-时间指数,提示不象枳实那样增加心肌的能量消耗。
Anesthetic dogs show that citrus aurantium and its active ingredient synephrine and N-methyl tyramine and dopamine, dobutamine, can significantly enhance a variety of myocardial contractility and pump blood function indicators: increased left ventricular pressure The peak of change rate and the shortening rate of myocardial contractile component (V_ (CE)) at the same maximum systolic pressure (CPIP), increased cardiac index (GI), decreased left ventricular time from start of systole to initiation of ejection, decreased Left ventricular end diastolic pressure. Since V CE at CPIP is unaffected by ventricular afterload (arterial pressure), it can be ruled out that the above mentioned increase is due to the influence of the drug on blood pressure. Because of Fructus aurantii and its active ingredients of cardiac, increase cardiac output and blood vessels to reduce the total peripheral resistance, leading to left ventricular pressure and arterial blood pressure, which is their pharmacological basis for anti-shock. N-methyl tyramine increased peripheral resistance than citrus aurantium and synephrine slightly weaker, but to speed up the role of heart rate is stronger. These two components are different in their function. Increasing the equivalent dose of heart rate index, citrus aurantium, synephrine, N-methyl tyramine and high-dose dopamine increased left ventricular work index and ejection ratio of the tension - time index far more than increased heart rate index This may be due to an increase in LV left ventricular afterload caused by. Dobutamine and low dose of dopamine is different from the citrus aurantium and its active ingredient is to reduce peripheral vascular resistance and reduce arterial blood pressure without significantly increasing the index of left ventricular work and ejection tension-time index, suggesting that unlike trifoliate orange Really increase myocardial energy expenditure.