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目的：了解ｐ５３蛋白、ｎｍ２３Ｈ１蛋白、表皮生长因子受体（ＥＧＦＲ）及癌胚抗原（ＣＥＡ）的表达与肿瘤局部复发的关系。方法：用ＡＢＣ免疫组化技术检测了ｐ５３、ｎｍ２３Ｈ１、ＥＧＦＲ、ＣＥＡ在２０例大肠癌原发及局部复发灶中的表达。结果：复发后ｐ５３阳性率显著增高，ｐ５３、ＥＧＦＲ及ＣＥＡ的表达程度均显著增加，ｎｍ２３Ｈ１阳性率及表达程度呈下降趋势。肿瘤复发后组织分化程度呈下降趋势。结论：复发大肠癌的生物学行为可能恶化，ｐ５３、ｎｍ２３Ｈ１、ＥＧＦＲ及ＣＥＡ在局部复发中可能起重要作用。
Objective: To investigate the relationship between the expression of p53 protein, nm23H1 protein, epidermal growth factor receptor (EGFR) and carcinoembryonic antigen (CEA) and local tumor recurrence. Methods: The expressions of p53, nm23H1, EGFR and CEA in primary and recurrent foci of 20 colorectal cancers were detected by ABC immunohistochemistry. Results: The positive rate of p53 was significantly increased after relapse, and the expression of p53, EGFR and CEA were significantly increased. The positive rate and expression of nm23-H1 showed a decreasing trend. After tumor recurrence, the degree of tissue differentiation showed a decreasing trend. CONCLUSIONS: The biological behavior of recurrent colorectal cancer may deteriorate, and p53, nm23-H1, EGFR, and CEA may play an important role in local recurrence.