THE IMPLICATION OF CENTRAL SEROTONIN IN ELECTRO-ACUPUNCTURE TOLE

• 作 者: 李思嘉 汤健 韩济生
• 机 构: Department of Physiology, Beijing Medical College,Department of Physiology, Beijing Medical College,
• 出 处: Science in China,Ser.B
• 发表日期: 1982年06期
• 关键词: analgesia morphine tolerant acupuncture flick stimulation conclusion prolonged a

Electro-acupuncture (EA) applied to both legs for 30min raised the tail flick latencyof the rat significantly. This effect of EA analgesia became attenuated and finally disap-peared after repeated EA stimulations, which was termed EA tolerance. EA tolerance and itscross tolerance to morphine analgesia were found to be partially reversed by intracerebro-ventricular injection of 5-hydroxytryptophan (5-HTP), the precursor of 5-hydroxytryptamine(5-HT). However, there was no depletion in cerebral 5-HT, nor was there decrease ofthe number of 5-HT receptors in the brain of the EA tolerant animals. Results obtainedfrom different lines of analysis point to the conclusion that development of tolerance toprofoundly released 5-HT during prolonged EA stimulation may constitute one of themechanisms for EA tolerance.

This effect of EA analgesia was attenuated and finally disap-peared after repeated EA stimulations, which was termed EA tolerance. EA tolerance and its cross tolerance to morphine analgesia were found to be created reversed by intracerebro-ventricular injection of 5-hydroxytryptophan (5-HTP), the precursor of 5-hydroxytryptamine (5-HT). However, there was no depletion in cerebral 5-HT, nor was there decrease of the number of 5-HT receptors in the brain of the EA tolerant animals. Results obtained from different lines of analysis point to the conclusion that development of tolerance toprofoundly released 5-HT during prolonged EA stimulation may constitute one of thechanisms for EA tolerance.