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干燥综合征(SS)是一种以侵犯泪腺、唾液腺等外分泌腺体为主的慢性自身免疫性疾病。目前SS的诊断尚缺乏特异度高的简便易行的检测方法,α-胞衬蛋白是从小鼠涎腺组织中提取的器官特异度自身抗原,与SS患者的发病机制密切相关。抗α-胞衬蛋白抗体是SS的一个标志性抗体,其对SS诊断的灵敏度和特异度国内外报道不一,总体来说,具有较低的灵敏度和较高的特异度,抗体阴性对于临床排除SS诊断意义不大,抗体阳性对于确定SS诊断可能具有更高的临床价值。近年来研究发现,抗α-胞衬蛋白抗体有可能为SS疾病早期的一项标志性抗体,而且与疾病活动相关。
Sjogren’s syndrome (SS) is a chronic autoimmune disease predominantly affecting exocrine glands such as the lacrimal gland and salivary gland. At present, the diagnosis of SS still lacks a simple and easy detection method with high specificity. Α-litterin is an organ-specific autoantigen extracted from the salivary gland tissue of mice, which is closely related to the pathogenesis of SS. Anti-α-litterin antibody is a SS antibody, the sensitivity and specificity of SS diagnosis reported at home and abroad vary, generally speaking, with lower sensitivity and higher specificity, antibody negative for clinical Excluding SS diagnosis is not significant, antibody positive for the diagnosis of SS may have a higher clinical value. In recent years, the study found that anti-α-litterin antibodies may be an early SS disease marker antibody, but also with disease activity.