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目的:验证慢性心力衰竭(CHF)患者的端粒长度短于与其年龄及性别相匹配的健康对照者的假说。背景:端粒长度被认为是生物学衰老的标记物。CHF可被认为是一种与衰老加速相关的病症。方法:在一项包括803例受试者的病例对照研究中,通过定量PCR的方法前瞻性测定了白细胞的端粒长度比。受试者包括183例健康人和620例CH F患者,年龄在40～80岁,NYH A心功能分级II～IV级,左室射血分数≤40%。结果:CH F患者的端粒长度比中位值为0.64(IQR0.47～0.88),
PURPOSE: To verify the hypothesis that telomere length in patients with chronic heart failure (CHF) is shorter than those of healthy controls matched to their age and gender. Background: Telomere length is considered as a marker of biological aging. CHF can be considered as a condition associated with accelerated aging. Methods: In a case-control study involving 803 subjects, the leukocyte telomere length ratio was prospectively determined by quantitative PCR. Subjects included 183 healthy subjects and 620 CHF patients aged 40 to 80 years, NYH Class A cardiac function class II to IV, and left ventricular ejection fraction 40%. Results: The median length to telomere length of CHF patients was 0.64 (IQR 0.47 to 0.88)