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经水迷宫、电磁流量计、同位素标记微球法及碱羟胺比色法对学习记忆障碍大鼠模型的学习记忆能力、脑血流量（Ｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ，ＣＢＦ）、海马和皮质的局部脑血流量（Ｒｅｇｉｏｎａｌｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ，ｒＣＢＦ）及乙酰胆碱（Ａｃｈ）含量进行测定。结果显示：醒脑胶囊（ＸＮ）组ＣＢＦ较脑复康、模型组均高，ＸＮ组、脑复康组大鼠皮质和海马的ｒＣＢＦ和Ａｃｈ含量均较模型组增加，且ＸＮ组海马ｒＣＢＦ和Ａｃｈ含量较脑复康组高；ＸＮ组学习记忆能力亦优于其它两组。提示，ＸＮ可改善多发脑梗塞大鼠的学习记忆缺损，其机理可能与ＣＢＦ或ｒＣＢＦ增加尤其是海马ｒＣＢＦ升高、Ａｃｈ含量增加密切有关。
Water maze, electromagnetic flowmeter, isotope-labeled microspheres, and alkalamine colorimetry were used to study memory ability, cerebral blood flow (CBF), regional cerebral blood flow in hippocampus and cortex of rats with learning and memory impairment (Regionalcerebralbloodflow). , rCBF) and acetylcholine (Ach) content were measured. The results showed that the CBF in the Xingnao Capsule (XN) group was higher than that in the Naofacon and model groups. The rCBF and Ach contents in the cortex and hippocampus of the XN and Naofukang groups were higher than those of the model group, and the rCBF of the hippocampus in the XN group was increased. The Ach content was higher than that of Naofukang group; the XN group also had better learning and memory ability than the other two groups. It is suggested that XN can improve learning and memory deficit in rats with multiple cerebral infarction. The mechanism may be related to the increase of CBF or rCBF, especially the increase of rCBF and Ach content in hippocampus.