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Coronary heart disease (CHD) is a major health problem in many countries and its pathogenesis is not yet fully understood, contributing to significant morbidity and mortality. Accumulated evidence manifest clearly that CHD is determined by a complex interplay of genetic and environmental factors. Many clinical data have showed that the renin-angiotensin system (RAS) involved in many cardiovascular diseases, such as hypertension and CHD. Angiotensinogen (AGT) is the key components of the RAS system, and two gene polymorphisms of AGT had been detected of the CHD risk: M235T and T174M. This article reviews the effects of AGT gene polymorphisms on the CHD.
Coronary heart disease (CHD) is a major health problem in many countries and its pathogenesis is not fully fully understood, contributing to significant morbidity and mortality. Accumulated evidence manifest clearly that CHD is determined by a complex interplay of genetic and environmental factors. Many clinical data have showed that the renin-angiotensin system (RAS) involved in many cardiovascular diseases, such as hypertension and CHD. Angiotensinogen (AGT) is the key components of the RAS system, and two gene polymorphisms of AGT had been detected of the CHD risk : M235T and T174M. This article reviews the effects of AGT gene polymorphisms on the CHD.