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采用前瞻性、纵向观察的方法，对269例孕妇从妊娠中期到晚期的平均动脉压（MAP）、抗凝血酶Ⅲ（AF-Ⅱ）含量、血浆纤维结合蛋白（Fn）含量的变化进行观察，其中32例发生妊高征。发病者与正常孕妇相比，Fn含量显著增高，而AT-Ⅲ含量、妊娠中期MAP变化不明显。取血浆Fn含量大于正常孕妇第90百分位数值预测妊高征，敏感性为68．75％，特异性为92.83％，较妊娠中期MAP≥12kPa预测妊高征的传统方法为高，可作为多种预测妊高征方法的补充。
The changes of mean arterial pressure (MAP), antithrombin Ⅲ (AF-Ⅱ) and plasma fibronectin (Fn) in 269 pregnant women from the second trimester to the late pregnancy were observed by prospective and longitudinal observation methods , Of which 32 cases of pregnancy-induced hypertension. Compared with normal pregnant women, the incidence of Fn was significantly higher, while the content of AT-Ⅲ and MAP in the second trimester of pregnancy were not significantly different. The plasma Fn content greater than the 90th percentile of normal pregnant women predicted pregnancy-induced hypertension, the sensitivity was 68.75% and the specificity was 92.83%, which was higher than the traditional method of predicting PIH during the second trimester MAP≥12kPa, A variety of methods to predict PIH supplement.