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微小病变为儿童肾病综合征的最常见病理类型,在成人病例中约占10～30%。局灶性肾小球硬化则为另一病理类型,该型对肾上腺皮质激素疗法常常不敏感,并容易发展为终末期肾衰,因而与微小病变型不同。已经发现微小病变可能转化为局灶性肾小球硬化。动物实验提示,预示转化的唯一指标可能是肾小球肥大。是否确实如此呢?作者进行了这个临床观察。对42例最初活检符合微小病变的儿童患者的活检
Minimal disease is the most common pathological type of childhood nephrotic syndrome, accounting for about 10 to 30% of adult cases. Focal glomerulosclerosis is another type of pathology that is often not sensitive to adrenocorticotropic hormone therapy and is prone to develop into end-stage renal failure and thus differs from minimal lesions. Minimal changes have been found to translate into focal glomerulosclerosis. Animal experiments suggest that the only indicator of conversion may be glomerular hypertrophy. Is this true? The authors conducted this clinical observation. Biopsy was performed on 42 children with minimal initial lesion on minimal biopsy