On-line coupling of derivatization with pre-concentration to determine trace levels of methotrexate

• 作 者: Samy Emara Tsutomu Masujima Wa
• 机 构: PharmaceuticalChemistryDepartment,AnalyticalMolecularMedicineandDevicesLaboratory.HiroshimaUniversit
• 出 处: 药物分析学报：英文版
• 发表日期: 2013年1期
• 关键词: 衍生 流水 预浓缩 磷酸盐缓冲液 跟踪 耦合 氨 自动填充 MethotrexateFlow injection analysisCerium （IV） tri

A new simple, sensitive and precise green analytical procedure using an automated packed-reactor derivatization technique coupled with on-line solid-phase enrichment (SPEn) has been developed and evaluated to determine trace levels of methotrexate (MTX).