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目的探讨地塞米松、氢化可的松、甲泼尼龙辅助治疗重症肺部感染的临床效果,以期提高临床治疗水平。方法随机选取2011年2月-2013年4月99例严重外伤后重症肺部感染患者为研究对象,分成3组,每组各33例,均在对症、抗感染等治疗的基础上分别予以地塞米松、氢化可的松、甲泼尼龙辅助治疗,观察治疗后临床效果差异性,数据采用SPSS13.0软件进行分析。结果地塞米松组的治愈率为27.27%,总有效率为69.69%;氢化可的松组的治愈率为30.31%,总有效率为75.76%,甲泼尼龙组的治愈率为69.7%,总有效率为93.94%;地塞米松组与氢化可的松组比较差异无统计学意义,甲泼尼龙组与其他两组比较差异有统计学意义(P<0.05);地塞米松组与氢化可的松组咳嗽、咳痰消失时间等症状改善以及第一秒最大呼气量和最大呼气流速峰值等肺功能比较差异无统计学意义,甲泼尼龙组与以上两组在各项指标中比较则差异均有统计学意义(P<0.05)。结论甲泼尼龙辅助治疗并发重症肺部感染临床效果较满意,但是要严格掌握适应证。
Objective To investigate the clinical effects of dexamethasone, hydrocortisone and methylprednisolone in the treatment of severe pulmonary infections in order to improve the clinical treatment. Methods From February 2011 to April 2013, 99 cases of severe post-traumatic severe pneumonia were randomly divided into 3 groups (33 cases in each group), which were treated respectively with symptomatic and anti-infective therapy Dexamethasone, hydrocortisone, methylprednisolone adjuvant therapy to observe the difference in the clinical effect after treatment, the data were analyzed by SPSS13.0 software. Results The cure rate of dexamethasone group was 27.27%, the total effective rate was 69.69%. The cure rate of hydrocortisone group was 30.31%, the total effective rate was 75.76%, the cure rate of methylprednisolone group was 69.7% The effective rate was 93.94%; there was no significant difference between dexamethasone group and hydrocortisone group, the difference between the methylprednisolone group and the other two groups was statistically significant (P <0.05); dexamethasone group and hydrocortisone group Of the pine group cough, sputum disappear time and other symptoms and the first second maximum expiratory volume and peak expiratory flow peak lung function was no significant difference between the methylprednisolone group and the above two groups in various indicators The differences were statistically significant (P <0.05). Conclusion The clinical effect of methylprednisolone adjuvant therapy for severe pulmonary infection is satisfactory, but the indications should be strictly controlled.