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目的观察米索前列醇不同给药途径用于绝经后妇女宫内节育器(intrauterine contraceptivedevice,IUD)取出术的效果。方法采用随机对照前瞻性研究方法,于术前2～4h应用米索前列醇400μg分别口服给药、阴道给药、舌下含化给药,观察宫颈软化情况和取器效果。结果宫颈软化率和取器成功率各组间差异均无统计学意义(P>0.05)。结论米索前列醇3种给药途径用于绝经后妇女取器的宫颈软化率和取器成功率无差异,口服给药有胃肠道反应,阴道给药易被稀释和冲出,影响药物吸收,故选择舌下含化给药更简便、安全和易行,值得临床推广。
Objective To observe the effect of different administration of misoprostol for the removal of intrauterine contraceptive device (IUD) in postmenopausal women. Methods A prospective randomized controlled trial was conducted in which 400 μg of misoprostol was given orally, vaginally and sublingually at 2 to 4 hours before operation. The cervix softening condition and the effect of the device were observed. Results There was no significant difference in cervical softening rate and success rate between two groups (P> 0.05). Conclusion The three routes of administration of misoprostol for postmenopausal women take the apparatus of cervical softening rate and success rate of no difference, oral administration of gastrointestinal reactions, vaginal administration easily diluted and washed out, the impact of drugs Absorption, so the choice of sublingual administration easier, safe and easy, worthy of clinical promotion.