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番瀉的液狀製劑在貯藏時,效力逐漸减失,此項事實早已为人所知,作者等利用樓之岑氏(ibid.,1949,1,673)所设計的生物測定法,證明了番瀉流浸膏的效力,是完全由於其中所含的番瀉苷A和B(Sennosides A and B)。然後用化學方法测定貯藏時各項因素,對於流浸膏中番瀉苷含量的影響,證明英國藥典1948所介紹的加熱至80℃三分鐘,並不能防止貯藏時的效價减失。貯藏在溫暖處(37℃),效價減失很快;加有乙醇(防腐劑)時,作用亦有顯著的減失。pH高於6或7時,作用減失亦快。最安定的pH是3—4,但在此pH時,番瀉苷容易沉澱。光線和空氣
The fact that the senna’s liquid preparation gradually loses its potency during storage has long been known. The authors used schizophrenia designed by Ibid. (1949, 1, 673) to prove senna The efficacy of flow extracts is entirely due to the sennosides A and B contained therein (Sennosides A and B). Then, chemical factors were used to determine various factors during storage. For the effect of sennoside content in stream extracts, it was proved that the British Pharmacopoeia 1948 introduced heating to 80°C for three minutes and could not prevent the reduction of potency during storage. Stored in a warm place (37°C), potency was quickly reduced; when ethanol (preservative) was added, the effect was also significantly reduced. When the pH is higher than 6 or 7, the loss of function is also faster. The most stable pH is 3-4, but at this pH, sennoside easily precipitates. Light and air