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早就知道当刺激心房压力受体时尿量和钠排泄增加,还证明了存在着心房—肾脏间神经经路,此外还指出了自心房向血液中释放某种具有钠利尿作用的物质,多数人认为在哺乳动物的心房肌细胞内有特异的心房颗粒,其形态学上具有多肽激素产生细胞存在的分泌颗粒特征的颗粒。因此设想由于伴随容量增加的心房壁紧张可使心房颗粒向血液中释放具有利尿作用的物质。1981年加拿大的de Bold在白鼠动物试验中提纯了调节体液的心房利尿因子(ANF),分子量在6,000以下的肽类物质,并单
It has long been known that when stimulating atrial pressure receptors, urine output and sodium excretion increase, it is also demonstrated that there is an atrial-renal pathway, in addition to the release of some substance with sodium diuretic properties from the atria to the bloodstream, most It is thought that there are specific atrial particles in mammalian atrial myocytes that morphologically have particles that are characteristic of secretory granules present by the polypeptide hormone producing cells. It is therefore assumed that the atrial particles release substances having a diuretic effect into the blood due to the tension of the atrial wall accompanying the increased capacity. In 1981, de Bold of Canada purified the atrial natriuretic factor (ANF) that regulates bodily fluid in animal experiments in rats, and peptides with molecular weights below 6,000