论文部分内容阅读
目的探讨Stathmin和Survivin在子宫内膜癌组织中的表达及临床意义。方法采用免疫组织化学法检测47例子宫内膜癌患者癌组织标本、47例不典型子宫内膜增生组织标本及30例正常子宫内膜组织标本中Stathmin和Survivin阳性表达情况,并分析Stathmin和Survivin阳性表达率与患者临床病理特征的关系。结果子宫内膜癌组织中Stathmin和Survivin阳性表达率显著高于子宫内膜增生组织及正常组织,差异有统计学意义(P<0.05);Stathmin和Survivin阳性表达与TNM分期、淋巴结转移、浸润深度显著相关(P<0.05),与病理分级无关(P>0.05)。结论 Stathmin和Survivin在子宫内膜癌发生、发展及转移中具有重要作用。
Objective To investigate the expression and clinical significance of Stathmin and Survivin in endometrial carcinoma. Methods Immunohistochemical method was used to detect the positive expression of Stathmin and Survivin in 47 cases of endometrial cancer tissues, 47 cases of atypical endometrial hyperplasia tissues and 30 cases of normal endometrial tissues. Stathmin and Survivin Relationship between positive expression rate and clinicopathological features of patients. Results The positive rates of Stathmin and Survivin in endometrial carcinoma were significantly higher than those in endometrial hyperplasia and normal tissues (P <0.05). The positive expressions of Stathmin and Survivin correlated with TNM stage, lymph node metastasis, depth of invasion (P <0.05), but not with pathological grade (P> 0.05). Conclusion Stathmin and Survivin play an important role in the occurrence, development and metastasis of endometrial carcinoma.