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目的探讨冠心病(CHD)并发糖尿病(DM)患者血清同型半胱氨酸(Hcy)、铜(Cu)的水平及二者的相关性。方法以31例CHD并发2型DM患者(DM组)为研究对象,以同期不并发DM的CHD患者36例为对照组(非DM组),另选择健康对照组30例,测定外周血Hcy、Cu浓度、体质指数和血脂。结果DM组血Hcy、Cu[分别为(18.8±3.5)、(21.1±3.8)μmol/L]高于健康对照组[分别为(10.7±2.3)、(16.8±2.7)μmol/L](P<0.01)和非DM组[分别为(15.6±1.9)、(14.8±2.2)μmol/L],均P<0.05;非DM组Hcy高于健康对照组(P<0.01),而Cu水平与对照组比较差异无统计学意义(P>0.05)。CHD并发DM组患者血Hcy与Cu呈正相关(P<0.01)。结论高Hcy致DM患者发生冠状动脉硬化可能与Cu的协同作用有关。
Objective To investigate the levels of serum homocysteine (Hcy) and copper (Cu) in patients with coronary heart disease (CHD) complicated with diabetes mellitus (DM) and their correlation. Methods Thirty-one CHD patients with type 2 DM (DM group) were enrolled in this study. Thirty-six CHD patients with no concurrent DM were selected as the control group (non-DM group). Another 30 healthy CHD patients were selected for determination of Hcy, Cu concentration, body mass index and lipids. Results The serum levels of Hcy and Cu in the DM group were (18.8 ± 3.5) and (21.1 ± 3.8) μmol / L, respectively, higher than those in the healthy controls [(10.7 ± 2.3) and (16.8 ± 2.7) μmol / L, respectively] (P <0.01) and non-DM group [(15.6 ± 1.9) and (14.8 ± 2.2) μmol / L, respectively] There was no significant difference in the control group (P> 0.05). There was a positive correlation between Hcy and Cu in patients with CHD complicated with DM (P <0.01). Conclusion The occurrence of coronary atherosclerosis in DM patients with high Hcy may be related to the synergistic effect of Cu.