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目的 观察 U5 0 ,488H(选择性 κ-阿片受体激动剂 )对大鼠腹主动脉的舒张作用 ,并探讨其机制 .方法 采用离体血管灌流实验 ,测定血管张力的改变 .结果 1U5 0 ,488H对大鼠腹主动脉具有明显的舒张作用 ;2 U5 0 ,488H对大鼠腹主动脉的舒张效应依赖于内皮细胞的存在 ;3优降糖可明显抑制 U5 0 ,488H对大鼠腹主动脉的舒张作用 ;4U5 0 ,488H的舒张血管效应与 M受体、β受体、前列腺素及 NO无关 .结论 U5 0 ,488H是一种有效的扩血管物质 ,其舒张血管的效应具有内皮依赖性 ,且与 K+ ATP通道有密切关系
Objective To observe the vasodilatory effects of U5 0, 488H (selective κ-opioid receptor agonist) on the abdominal aorta in rats and to explore its mechanism.Methods Vascular in vitro perfusion was used to measure the changes of vascular tone.Results 1U5 0, 488H has a significant relaxation effect on the abdominal aorta; 2 U5 0, 488H on the abdominal aorta in rats depends on the diastolic effect of the presence of endothelial cells; 3 glibenclamide significantly inhibited U5 0, 488H on the abdominal aortic Arterial diastolic function was not observed in all the rats.Unitheory of vasodilatation of 4U50, 488H was not related to M receptor, β receptor, prostaglandin and NO.Conclusion U5 0, 488H is an effective vasodilator with vasodilator endothelium-dependent Sex, and K + ATP channels are closely related