Maltose-binding Protein Improving the Crystallizability of C2 Domain of Human Coagulation Factor Ⅴ

• 作 者: CHEN Song WANG Yu ZHAO Bao-Yu
• 机 构: StateKeyLaboratoryofStructuralChemistry,GraduateSchoolofChineseAeademyofSciences
• 出 处: 结构化学
• 发表日期: 2014年2期
• 关键词: 麦芽糖结合蛋白 C2结构域 凝血因子V 分子间相互作用 晶体结构 结晶 凝血酶原 细胞表面 maltose-binding protein coagulati
• 基金项目: Supported by the National Natural Science Foundation of China （31161130356）

Human coagulation Factor V(FV), together with Factor Xa, assembles to prothrombinase complex on activated cell surface, which converts prothrombin into thrombin, leading to fibrin deposition. The C2 domain of FV is believed to be a primary anchor for the