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为观察中药８１４ 对肺炎克雷伯杆菌诱发大鼠慢性阻塞性肺疾病（ＣＯＰＤ） 是否有影响， 用经鼻腔注入， 反复感染法建立大鼠ＣＯＰＤ模型。大鼠分为正常对照、感染、预防治疗、一般治疗和假治疗组。预防治疗组和一般治疗组大鼠分别于细菌感染前３ ｄ 和细菌感染后第４ 周开始用中药８１４灌胃治疗。结果表明， 两治疗组尤其是前者大鼠气管、细支气管和肺泡上皮细胞损伤轻微， 细支气管壁和肺间质炎症亦较感染组为轻。与感染组相比较，预防治疗组第８周起和一般治疗组第１６ 周大鼠单位面积内平均肺泡数增加 （Ｐ＜ ０．０５）， 第１６ 周， 预防治疗组大鼠血氧分压比感染组增高（Ｐ＜ ０．０５）， 血ＣＯ２ 分压降低 （Ｐ＜ ０．０５）， 两指标均接近正常水平。结果提示， 中药８１４ 对诱发大鼠ＣＯＰＤ有较明显干预作用
In order to observe whether Chinese medicine 814 has influence on chronic obstructive pulmonary disease (COPD) induced by Klebsiella pneumoniae in rats, COPD model was established by intranasal injection and repeated infection. Rats were divided into normal control, infection, preventive treatment, general treatment and sham treatment groups. The rats in the preventive treatment group and the general treatment group were treated with traditional Chinese medicine 814 before 3 days before bacterial infection and 4 weeks after bacterial infection. The results showed that the trachea, bronchioles, and alveolar epithelial cells in the two treatment groups, especially the former rats, were slightly damaged, and the bronchiolar wall and interstitial inflammation were also milder than those in the infected group. Compared with the infected group, the average number of alveolar cells per unit area increased from week 8 in the preventive treatment group to week 16 in the general treatment group (P<0.05). At week 16, the oxygen partial pressure of blood in the prophylactic treatment group rats was increased. Compared with the infection group (P<0.05), the partial pressure of blood CO2 decreased (P<0.05), both indicators were close to normal levels. The results suggest that traditional Chinese medicine 814 has a significant intervention effect on rat COPD