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治疗支气管及肺部细菌感染的成功或失败,其重要因素之一是合宜抗生素浓度在呼吸道感染部位的(氵弥)散,多数文献应用动物模型或痰液作为研究手段或标本。本文应用气管插管、气管造瘘或纤维支气管镜等方法以获得不为上呼吸道分泌物或唾液所污染的下呼吸道支气管分泌液。此类标本的测定结果可代表游离药物在肺部的有效浓度、药物的透入速度、在肺部的代谢和分泌液的廓清等因素。采用一次给药后检查380例无肝、肾功能损害的慢性支气管炎患者,在他们继发呼吸道感染时取痰液标本,同时收集给药后不
One of the most important factors in the success or failure of bronchial and pulmonary bacterial infections is the appropriate concentration of antibiotics in respiratory tract infections. Most studies use animal models or sputum as a research tool or specimen. This article uses endotracheal intubation, tracheostomy or bronchoscopy and other methods to obtain not for the upper respiratory secretions or saliva of the lower respiratory tract bronchial secretions. The results of such specimens may represent the effective concentration of free drug in the lungs, drug penetration rate, metabolism in the lungs and the clearance of secretions and other factors. 380 cases of chronic bronchitis without liver damage and renal dysfunction were examined after one administration, sputum samples were taken when they were secondary to respiratory infection,