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新生儿破伤风常规疗法,虽然用大剂量镇静剂和机械呼吸的疗法可显著降低其病死率。但是,这种治疗较为复杂,难以广泛使用。人们希望能有一个针对破伤风毒素使神经肌肉传递紊乱的机理来进行治疗的新疗法。目前有证据提示破伤风毒素主要作用于运动神经元突触部位和突触前神经末梢,并通过抑制其对神经传递有抑制作用的化学物质——r-氨基丁酸
Conventional neonatal tetanus therapy, although the use of high-dose sedatives and mechanical respiration therapy can significantly reduce its mortality. However, this treatment is complicated and difficult to use widely. It is hoped that there will be a new therapy for the treatment of tetanus toxins that disrupts neuromuscular transmission. There is evidence that tetanus toxin acts primarily on the synaptic and synaptic terminals of motor neurons and inhibits neurotransmission by inhibiting the translocation of r-aminobutyric acid