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Becher和Granger首先在生物化学方面用特异酶化验证明包括腕管病变在内的临床综合征病人有维生素B_6即磷酸吡哆醇的缺乏。用磷酸吡哆醇治疗这些病人以纠正维生素B_6的缺乏,获得显著临床进步,并得到肌电图的证实。病人10名,包括男女两性、年龄33～69岁。用红细胞谷草转氨酶(EGOT)特异检验判明10名病人均有阴显的维生素B_6缺乏。这种转氨酶的活性需要磷酸吡哆醇,EGOT的活性下降幅度为21～31％,平均为26.8±3.4％。该数值明显高于对照数值12±7％(P<0.001)。每天口服盐酸吡哆醇300毫克治疗2～4周,测验结果分别为1.6±4.5％和0.32±6.5％。此百分率同治疗前的平均下降值26.8±3.4％有明显的差别(P<0.001)。在生物化学和代谢方面的重要意义是用吡哆醇治疗2～4周使此种转氨酶活性水平增加55～68％,其对比活性比治疗前明显增高。EGOT活性明显增高表明酶蛋白(Apoenzy-
Becher and Granger first biochemical tests using specific enzymes to prove that clinical syndromes, including carpal tunnel lesions in patients with vitamin B_6 phosphorylation of pyridoxine deficiency. Treatment of these patients with pyridoxine phosphate to correct for the lack of vitamin B_6 resulted in significant clinical improvement and was confirmed by electromyography. 10 patients, including both men and women, aged 33 to 69 years. Specific tests using erythrocyte aspartate aminotransferase (EGOT) found that 10 patients had significant vitamin B_6 deficiency. This transaminase activity requires pyridoxine phosphate, with a 21 to 31% decrease in EGOT activity and an average of 26.8 ± 3.4%. This value was significantly higher than the control value of 12 ± 7% (P <0.001). Daily oral pyridoxine hydrochloride 300 mg for 2 to 4 weeks, the test results were 1.6 ± 4.5% and 0.32 ± 6.5%. This percentage was significantly different from the mean decrease of 26.8 ± 3.4% before treatment (P <0.001). The significance of biochemistry and metabolism is that treatment with pyridoxine for 2 to 4 weeks increases this aminotransferase activity level by 55 to 68% and its comparative activity is significantly higher than before treatment. EGOT activity was significantly higher enzyme protein (Apoenzy-