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苯妥英(DPH)是一种有效的抗癫痫药物,用于小发作的治疗。关于它的生物利用度已有综述。口服苯妥英后的吸收取决于它本身的物理化学性质,它主要是通过非离子型的被动扩散而从小肠吸收。苯妥英的血药浓度与剂量有关,在剂量为4～14mg/kg/日的范围内,血药浓度随着剂量的增加而成比例的增加,半寿期恒定在24小时左右。当剂量超过上述范围时,略微增加剂量,则血药浓度大幅度地上升,半寿期则延长,临床可出现副作用。
Phenytoin (DPH) is a potent antiepileptic drug used in the treatment of small seizures. The bioavailability of it has been reviewed. The absorption after oral administration of phenytoin depends on its own physico-chemical properties, and it is mainly absorbed from the small intestine by non-ionic passive diffusion. The plasma concentration of phenytoin is dose-dependent. At a dose of 4 to 14 mg / kg / day, plasma concentration increases proportionally with increasing dose, and the half-life is constant at around 24 hours. When the dose exceeds the above range, a slight increase in dose, the plasma concentration increased significantly, half-life is prolonged, clinical side effects can occur.