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异烟肼对于结核杆菌的作用机制目前尚未完全阐明,有资料证明异烟肼首先与金属Ca~(2+)、Fe~(2+)等形成螯合物,然后再影响酶系统而发挥作用。同时异烟肼为一螯合剂,与杆菌酶系统中的镁离子螯合,从而干扰了结核杆菌的代谢,抑制其生长。基于上述作用机理,如果患者在口服异烟肼期间,伍用硫酸亚铁、三硅酸镁、氢氧化铝等药物,由于相互间的作用和影响,可使异烟肼生物效应降低。异烟肼分子结构中含有肼类功能团(—NHNH_2)称配位体,遇到铁、镁、铝等金属离子,由于两者间的相互作用,配位体可将其孤对电子填入中心离子的空轨道,形成
Isoniazid for Mycobacterium tuberculosis mechanism has not yet been fully elucidated, there is data to prove that isoniazid first with the metal Ca ~ (2 +), Fe ~ (2+) to form chelates, and then affect the enzyme system and play a role . At the same time isoniazid as a chelating agent, with the enzyme in the enzyme system chelating magnesium ions, thus interfering with the metabolism of Mycobacterium tuberculosis, inhibiting its growth. Based on the above mechanism of action, if the patient during the period of oral isoniazid, the use of ferrous sulfate, magnesium trisilicate, aluminum hydroxide and other drugs, due to the interaction between each other and can reduce the biological effects of isoniazid. Isoniazid molecular structure contains hydrazine functional group (-NHNH_2) called ligand, met with iron, magnesium, aluminum and other metal ions, due to the interaction between the two ligands can lone their electronic fill The empty orbit of the center ion forms