尼群地平及卡托普利对高血压大鼠糖脂代谢的影响

• 作 者: 苏海 李菊香 罗伟
• 出 处: 江西医学院学报
• 发表日期: 1994年04期
• 关键词: 尼群地平 高血压大鼠 糖脂代谢 药物作用 血胰岛素水平 降压药物 糖代谢 钙通道阻滞剂 脂类 血胆固醇

用尼群地平与卡托普利分别治疗１４周龄的自发性高血压大鼠（ＳＨＲ）１４周，治疗期间使两组血压下降水平相当。结果表明：尼群地平治疗ＳＨＲ组较对照ＳＨＲ组血胆固醇及血糖有明显下降，而甘油三酯，高密度脂蛋白，血胰岛素水平无明显改变。卡托普利治疗ＳＨＲ组上述各参数均无明显改变。两种降压药物均不产生血脂及糖代谢的不利影响，尼群地平并有改善作用。

Nitrofuranto and captopril were used to treat 14-week-old spontaneously hypertensive rats (SHRs) for 14 weeks, respectively, resulting in a comparable decrease in blood pressure during the treatment period. The results showed that nitrendipine treatment of SHR group than the control SHR group, blood cholesterol and blood glucose decreased significantly, while triglyceride, high-density lipoprotein, blood insulin levels did not change significantly. Captopril treatment SHR group of the above parameters had no significant change. Two antihypertensive drugs do not produce adverse effects of blood lipids and glucose metabolism, nitrendipine and improve the role.