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目的 评价盐酸苯那普利药品在以社区为基础的原发性高血压患者人群中使用的降压效果和安全性。方法 连续收集了 1831例服用盐酸苯那普利药的原发性高血压患者的 18个月用药记录 ,包括血压水平、用药和不良反应情况等。结果 患者人群既往服药患者占 1/ 3,按规定服药和单独服用盐酸苯那普利者占 96 %以上。盐酸苯那普利的有效率从 3个月的 73.6 %上升到 18个月的84.7% ,各种特征的患者均有效。 18个月的血压下降幅度为收缩压 /舒张压 1.4/ 0 .9kPa(10 .8/ 6 .7mmHg)。 416人出现不良反应 ,发生率 2 2 .7% ,主要不良反应类型是咳嗽。首次发生不良反应的高峰出现在治疗的前 3个月内 ,轻度占近 6 0 %。结论 长期服用盐酸苯那普利的降压效果是肯定的 ,同时又是安全的。
Objective To evaluate the antihypertensive efficacy and safety of benazepril hydrochloride in community-based patients with essential hypertension. Methods A total of 1831 medication records were collected from 1831 patients with essential hypertension taking benazepril hydrochloride, including blood pressure, medication, and adverse reactions. Results The patient population previously took 1/3 of the patients taking the medication, and prescribed benazepril alone took more than 96%. The efficacy of benazapheline hydrochloride rose from 73.6% at 3 months to 84.7% at 18 months, and patients with various traits were effective. 18-month reduction in blood pressure systolic / diastolic 1.4 / 0 .9kPa (10 .8 / 6 .7mmHg). 416 people showed adverse reactions, the incidence of 22.7%, the main type of adverse reactions is cough. The first peak of adverse events occurred within the first 3 months of treatment, with a mild prevalence of 60%. Conclusion Long-term benazepril hydrochloride hypotensive effect is positive, but also safe.