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我们曾经报道,给大鼠脑室注射 cAMP,外源性地提高脑内 cAMP 水平,引起大鼠的电针镇痛效应显著减弱,并有明显的剂量效应关系。已知裂解 cAMP 的磷酸二酯酶(PDE)抑制剂茶碱能提高脑内 cAMP 含量,而 PDE 激活剂咪唑则能降低脑内 cAMP 水平。因此本文用脑室注射 PDE 抑制剂氨茶碱或 PDE 激活剂咪唑的方法以图改变中枢内源性 cAMP 的水平时对电针镇痛的影响。结果表明氨茶碱能拮抗电针镇痛,而咪唑则对电针镇痛有加强作用。这与外源性注射 cAMP 的结果一致,说明脑内 cAMP 可能是对抗电针镇痛的一个重要因素。
We have previously reported that intracerebroventricular (icv) injection of cAMP exogenously increases cAMP levels in the rat brain causing a significant reduction in electroacupuncture analgesia and a dose-response relationship. It is known that theophylline, a phosphodiesterase (PDE) inhibitor that cleaves cAMP, increases brain cAMP levels, whereas the PDE activator imidazole decreases brain cAMP levels. Therefore, this article intraventricular injection of PDE inhibitor aminophylline or PDE activator imidazole in order to change the central endogenous cAMP levels on the impact of electroacupuncture analgesia. The results showed that aminophylline can antagonize electroacupuncture analgesia, while the role of imidazole enhanced analgesia on electroacupuncture. This is consistent with the results of exogenous cAMP injection, suggesting that intracerebral cAMP may be an important factor in counteracting electroacupuncture analgesia.