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自1948年Ahlquist将肾上腺素能受体分为α和β两型以后,Furchgott和Lands等又将β受体分为β_1和β_2两个亚型。近十年来Langets又首先提出:将调节效应器官反应的突触后α受体命名为α_1受体,而将突触前膜上调节去甲肾上腺素释放的α受体命名为α_2受体。因这种α_2受体的调节作用除具有重要的生理和药理意义外,还具有重要的临床意义。本文扼要介绍这方面研究的进展。
Since Ahlquist divided adrenergic receptors into α and β types in 1948, Furchgott and Lands, in turn, divided β receptors into β 1 and β 2 subtypes. In the last decade, Langets first proposed that the post-synaptic alpha receptor that regulates organ response is named as the alpha 1 receptor and the norepinephrine-regulated alpha receptor on the presynaptic membrane is named the alpha 2 receptor. Because of the regulation of this α 2 receptor in addition to the important physiological and pharmacological significance, but also has important clinical significance. This article outlines the research progress in this area.