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去甲斑蝥素的毒性,虽然远比斑蝥素毒为小,但由于它的临床使用前景,就有必要对其毒性作用进行细致的观察。基于此目的,我们对去甲斑蝥素可能导致的肝组织损伤进行病理形态学研究。实验方法和结果使用昆明种小鼠,分四组进行观察: 去甲斑蝥素小剂量组(11只小鼠)1/10LD_(50)(小鼠腹腔)的去甲斑蝥素配制成0.025mg/ml,以0.5ml/10g剂量进行腹腔注射,每日二次,共两天。去甲斑蝥素大剂量组(14只小鼠):1/5LD_(50)(小鼠腹腔)的去甲斑蝥素配制成
Although the toxicity of norcantharidin is far less than that of cantharidin, due to its clinical use prospects, it is necessary to carefully observe its toxic effects. For this purpose, we performed pathomorphological studies on liver tissue damage that may be caused by norcantharidin. Experimental methods and results Kunming mice were used and divided into four groups for observation: In the low dose group of norcantharidin (11 mice), 1/10 LD_(50) (peritoneal cavity of the mouse), norcantharidin was formulated to 0.025 mg/ml Ml, intraperitoneally administered in 0.5 ml/10 g dose twice daily for two days. A large dose of norcantharidin (14 mice): 1/5LD_(50) (peritoneal cavity of mice) formulated with norcantharidin