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儿童犬弓蛔虫感染后引起癫痫样发作并不罕见,尤其在学龄前儿童更易见到。我们对305例儿童(其中91例有发作病史,214例作为对照)作全面研究来评估弓蛔虫病与癫痫的关系。发作组中20例(22%)发现有抗弓蛔虫抗体,对照组中26例(12.1%)为阳性(P<0.05)。虽然抗弓蛔虫抗体随年龄逐渐增加,但抗弓蛔虫抗体在5岁以下癫痫儿童中很明显增高。我们的资料认为,有惊厥发作的儿童抗弓蛔虫抗体升高。但弓蛔虫病与癫痫之间的关系仍有争议。一些有癫痫发作的儿童有典型的异常行为(如:异食癖、过度兴奋),可能有受弓蛔虫感染的素因。但我们也观察到有癫痫发作的小儿与犬的密切接触有关。这也能更好地解释家族群体性弓蛔虫病。
It is not uncommon for pediatric canine ascaris infection to cause epileptic seizures, especially in preschool children. We conducted a comprehensive study of 305 children (91 of whom had a history of seizures and 214 as controls) to assess the association between ascariasis and epilepsy. In the attack group, antibodies against Toxocariasis were found in 20 cases (22%) and in control group (12.1%) (P <0.05). Although anti-roundworm antibodies gradually increased with age, anti-roundworm antibodies were significantly increased in children under 5 years of age with epilepsy. Our data suggest that children with anticonvulsant anti-Toxoplasma gondii antibodies increased. However, the relationship between ascariasis and epilepsy is still controversial. Some children with seizures have typical abnormal behavior (eg, pica, over-excitement) and may have a cause of infection with Ascaris suum. However, we also observed the close contact between children with seizures and dogs. This can also better explain familial condylomata acuminata.